Sasaki T, Kadono T, Endo F, Sekiguchi Y, Saito T, Arakawa M, Furuyama T, Yoshinaga K
Tohoku J Exp Med. 1982 Dec;138(4):341-55. doi: 10.1620/tjem.138.341.
Hemolytic (complement-fixing) antibodies to single-stranded (ss) or double-stranded (ds) DNA, measured by recently developed PHL assay, occurred closely correlated with renal activity in patients with systemic lupus (SLE). Approximately one third of the patients with renal disease had hemolytic antibodies to ss-DNA but never to ds-DNA. Hemolytic antibodies were scarcely detectable in patients with mild course. Serial studies also revealed that the estimation of the hemolytic antibodies to ds- and/or ss-DNA was particularly valuable in predicting the future course of the SLE. The emergence of hemolytic antibodies to DNA may be an ominous sign suggestive of grave prognosis in SLE.
通过最近开发的PHL检测法测量的针对单链（ss）或双链（ds）DNA的溶血（补体结合）抗体，与系统性红斑狼疮（SLE）患者的肾脏活动密切相关。大约三分之一的肾病患者有针对ss-DNA的溶血抗体，但从未有针对ds-DNA的溶血抗体。轻度病程的患者几乎检测不到溶血抗体。系列研究还表明，对ds-和/或ss-DNA溶血抗体的评估在预测SLE的未来病程方面特别有价值。针对DNA的溶血抗体的出现可能是SLE预后不良的不祥征兆。
