Charpentier B, Lang P, Martin B, Fries D
Biomed Pharmacother. 1982;36(5):250-4.
Cimetidine, an H2-receptor antagonist had no immunoproliferative or immunostimulative effect on in vitro T cell functions of normal human peripheral blood lymphocytes. This was shown by adding Cimetidine to mitogen, alloantigen and xenoantigen-stimulated cultures. Generation of helper and cytotoxic T cells was not modified in a full kinetic experiment. These data failed to confirm previous reports showing an increase of cell-mediated immunity under Cimetidine therapy.
西咪替丁，一种H2受体拮抗剂，对正常人外周血淋巴细胞的体外T细胞功能没有免疫增殖或免疫刺激作用。这是通过将西咪替丁添加到有丝分裂原、同种异体抗原和异种抗原刺激的培养物中得到证明的。在一项完整的动力学实验中，辅助性T细胞和细胞毒性T细胞的生成没有改变。这些数据未能证实先前的报道，即西咪替丁治疗可增强细胞介导的免疫。
