[Clinical evaluation of anticancer therapy combined with p-aminobenzoic acid-N-xyloside].
作者信息
Fujimoto S, Ishigami H, Okui K
出版信息
Gan To Kagaku Ryoho. 1982 Sep;9(9):1574-9.
PMID:6985199
Abstract
Paraaminobenzoic acid-N-xyloside (K-247) is a new antitumor drug, which has no direct effect on immunologic status. Clinical trial of K-247 was performed in 8 patients with for advanced or recurred gastrointestinal cancer, who had short life expectancy. Oral administration of K-247, 600 to 900 mg/day, was carried out in combination with antitumor treatments using MMC, FT-207, 5-FU, PSK or irradiation. No toxic symptoms were observed in all patients. Of the 8 patients studied, one showed an encouraging response, while the remaining 7 patients were too far advanced to respond to these treatments.
摘要
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