Gajewski F, Makulska H E, Misterek K, Stochla K
Pol J Pharmacol Pharm. 1982 Nov-Dec;34(5-6):365-72.
4-propionyl-4-(4-chlorophenyl)-1-(3-dimethylaminopropyl)-piperidine dihydro-chloride (S8) showed in the hot plate test a marked analgesic activity with a better therapeutic index than that of pethidine. S8 possesses also anti-inflammatory (in short and long-term tests in vivo) as well as spasmolytic properties.
4-丙酰基-4-(4-氯苯基)-1-(3-二甲基氨基丙基)哌啶二盐酸盐（S8）在热板试验中显示出显著的镇痛活性，其治疗指数优于哌替啶。S8还具有抗炎作用（体内短期和长期试验）以及解痉特性。
