Dumitrescu C, Georgescu M
Clinic of Nutrition and Metabolic Diseases, Dr. I. Cantacuzino Hospital, Bucharest, Romania.
Med Interne. 1982 Jan-Mar;20(1):19-24.
Uric acid assays were performed in the blood serum from 20 obese patients (19 women and 1 man, with a mean age of 39.75 +/- 8.16 years), before and after an average period of three weeks of hypocaloric diet (400-500 cal/day) during which they lost about 8 kg of body weight each. The variations of uricemia were followed up in relation with the weight loss and with the presence or absence of changes in the plasma lipid values. The mean rise of uricemia in the whole lot of subjects, as well as in those who lost more than 8 kg b.w. were weakly significant, as compared to the initial values. In the patients distributed according to the changes of lipid values, the increase was not significant. In conditions of rapid weight loss, even when the diet was supplemented by 70 g proteins/day, the serum uric acid values rose up to the limit of plasma urate solubility. This imposes a periodical check-up of uricemia, at the beginning, in the course and at the end of the periods of rapid weight loss, in view of detecting and correcting the eventual disorders which might occur in such conditions.
对20名肥胖患者（19名女性和1名男性，平均年龄39.75±8.16岁）的血清进行尿酸检测，检测在平均为期三周的低热量饮食（400 - 500卡路里/天）前后进行，在此期间他们每人减重约8千克。对血尿酸的变化进行跟踪，观察其与体重减轻以及血浆脂质值有无变化之间的关系。与初始值相比，所有受试者以及体重减轻超过8千克体重的受试者的血尿酸平均升高幅度微弱显著。在根据脂质值变化分类的患者中，升高并不显著。在快速减重的情况下，即使饮食中每天补充70克蛋白质，血清尿酸值也会升至血浆尿酸盐溶解度的极限。鉴于可能在此类情况下发生的最终紊乱需要检测和纠正，因此在快速减重期开始、过程中和结束时，都要定期检查血尿酸。
