Wiktor-Jedrzejczak W, Siekierzynski M, Rychowiecka E, Bukowska B, Czarnecki C
Department of Nuclear Medicine, Postgraduate Center Military School of Medicine, Warsaw, Poland.
Med Interne. 1982 Oct-Dec;20(4):289-94.
In fifteen patients treated for lung cancer with a combination of vincristine (VCR) (2 x 0.325 mg/kg), amethopterin (MTX) (3 x 0.4 mg/kg) and cyclophosphamide (CY) (30-50 mg/kg) at monthly intervals the peripheral blood parameters were determined every 2-4 days. The values of these parameters including neutrophils, lymphocytes, platelets, erythrocytes and reticulocytes decreased uniformly reaching the lowest level about the 11th day post each course of chemotherapy. Subsequently, by the 17th day, the values of all these parameters except the red cell count returned to the pretreatment levels. The only parameter whose nadir value was associated with known risk to the health was the absolute neutrophil count. The period of dangerous decrease of this count began on the 6th day and ended approximately on the 17th day after cyclophosphamide infusion. Repeated courses had no additive toxicity since the time interval between courses allowed for hematopoietic recovery. However, the gradual decrease in the red cell count was observed during intermittent chemotherapy.
在15例接受长春新碱（VCR）（2×0.325毫克/千克）、氨甲蝶呤（MTX）（3×0.4毫克/千克）和环磷酰胺（CY）（30 - 50毫克/千克）联合治疗肺癌的患者中，每月进行一次治疗，每2 - 4天测定外周血参数。这些参数的值，包括中性粒细胞、淋巴细胞、血小板、红细胞和网织红细胞，均呈一致下降，在每个化疗疗程后约第11天达到最低水平。随后，到第17天，除红细胞计数外，所有这些参数的值均恢复到治疗前水平。唯一其最低点值与已知健康风险相关的参数是绝对中性粒细胞计数。该计数危险下降期始于环磷酰胺输注后第6天，大约在第17天结束。由于疗程之间的时间间隔允许造血恢复，重复疗程无累积毒性。然而，在间歇化疗期间观察到红细胞计数逐渐下降。
