David D S, Cheigh J S, Braun D W, Fotino M, Stenzel K H, Rubin A L
JAMA. 1980 Feb 8;243(6):532-3.
Between July 1971 and March 1977, steroid-induced diabetes (SD) developed postoperatively in 31 (10.8%) of 286 nondiabetic adult kidney transplant recipients who were observed for a total of 410 patient transplant years. There was a highly significant association between HLA-A28 and SD. There was no significant association between SD and BB or Bw 15. Age was also associated with SD. However, A28 was associated with SD even when corrected for age. A28 occurred more frequently in blacks than whites, 25.4% and 6.3%, respectively, and accounted for the higher incidence of SD in black adults. There were no significant associations between SD and patients' sex, donor source, number of short-term rejection treatments, or maintenance dose of corticosteroids. Steroid-induced diabetes had no adverse effects on graft or patient survival.
1971年7月至1977年3月期间，在286名非糖尿病成年肾移植受者中，有31名（10.8%）在术后出现了类固醇诱导的糖尿病（SD），这些受者的观察期总计为410个患者移植年。HLA - A28与SD之间存在高度显著的关联。SD与BB或Bw15之间无显著关联。年龄也与SD有关。然而，即使校正年龄后，A28仍与SD相关。A28在黑人中的出现频率高于白人，分别为25.4%和6.3%，这也解释了成年黑人中SD发病率较高的原因。SD与患者的性别、供体来源、短期排斥治疗次数或皮质类固醇维持剂量之间均无显著关联。类固醇诱导的糖尿病对移植物或患者存活没有不良影响。
