Christensen K K, Ingemarsson I, Leideman T, Solum T, Svenningsen N
Obstet Gynecol. 1980 Feb;55(2):187-90.
The effect on labor of administering ritodrine after a premature rupture of the membranes (PROM) was studied in a double-blind trial in 30 patients. The patients were selected according to the following criteria: 28 to 36 weeks' gestation, only 1 fetus, cervix dilated 4 cm or less, and absence of pyrexia or other signs of uterine infection. Fourteen patients received ritodrine and 16 received a placebo. The 2 groups were statistically comparable. None of the patients receiving ritodrine delivered within 24 hours. The difference between the 2 groups was statistically significant with respect to the number of patients delivered within 24 hours (P less than 0.05). However, after 24 hours, there was no difference between the groups as regards the length of pregnancy. The infections registered in the mothers of infants were few and easily controlled. The incidence of idiopathic respiratory distress syndrome (IRDS) was low in the study and allows no conclusions concerning the benefit of prolonging the pregnancy for more than 24 hours after PROM.
在一项针对30名患者的双盲试验中，研究了胎膜早破（PROM）后使用利托君对分娩的影响。患者根据以下标准选择：妊娠28至36周，单胎，宫颈扩张4厘米或以下，无发热或其他子宫感染迹象。14名患者接受利托君治疗，16名患者接受安慰剂治疗。两组在统计学上具有可比性。接受利托君治疗的患者在24小时内均未分娩。两组在24小时内分娩的患者数量上差异具有统计学意义（P小于0.05）。然而，24小时后，两组在妊娠时长方面没有差异。婴儿母亲中记录的感染很少且易于控制。本研究中特发性呼吸窘迫综合征（IRDS）的发生率较低，无法得出关于胎膜早破后延长妊娠超过24小时是否有益的结论。
