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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Oates N S, Perkins C M, Lee M R

Clin Sci (Lond). 1980 Jan;58(1):77-82. doi: 10.1042/cs0580077.

Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0.2 mg twice daily). 3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal. 4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid 'escape' then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.

对5名正常受试者在钠和钾摄入量受控的代谢条件下进行了研究。2. 在这些受试者中，于每日两次服用氟氢可的松（0.2毫克）5天之前、期间和之后测量血浆和尿中游离多巴胺浓度。3. 尿中游离多巴胺在氟氢可的松给药早期呈下降趋势，随后又回升至正常水平。4. 在一名原发性醛固酮增多症患者中，没有证据表明肾脏多巴胺生成增加。当因服用螺内酯（每日三次，每次200毫克，共5天）导致血浆肾素活性升高时，尿多巴胺下降。5. 如果肾脏多巴胺在盐皮质激素“逃逸”中起作用，那么它可能只是起允许作用。多巴胺生成的控制机制可能包括肾小管钠浓度、肾小管氯浓度和肾内肾素活性。

Oates N S, Perkins C M, Lee M R

Clin Sci (Lond). 1980 Jan;58(1):77-82. doi: 10.1042/cs0580077.

Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0.2 mg twice daily). 3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal. 4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid 'escape' then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.

对5名正常受试者在钠和钾摄入量受控的代谢条件下进行了研究。2. 在这些受试者中，于每日两次服用氟氢可的松（0.2毫克）5天之前、期间和之后测量血浆和尿中游离多巴胺浓度。3. 尿中游离多巴胺在氟氢可的松给药早期呈下降趋势，随后又回升至正常水平。4. 在一名原发性醛固酮增多症患者中，没有证据表明肾脏多巴胺生成增加。当因服用螺内酯（每日三次，每次200毫克，共5天）导致血浆肾素活性升高时，尿多巴胺下降。5. 如果肾脏多巴胺在盐皮质激素“逃逸”中起作用，那么它可能只是起允许作用。多巴胺生成的控制机制可能包括肾小管钠浓度、肾小管氯浓度和肾内肾素活性。