来自北美乔柏的崖柏素作为鼠伤寒沙门氏菌的铁转运剂。
Thujaplicins from Thuja plicata as iron transport agents for Salmonella typhimurium.
作者信息
Akers H A, Abrego V A, Garland E
出版信息
J Bacteriol. 1980 Jan;141(1):164-8. doi: 10.1128/jb.141.1.164-168.1980.
Abstract
Strains of Salmonella typhimurium which are unable to synthesize their normal iron transport agent, enterobactin, and which must be supported with an exogenous chelator (siderophore) on certain media, were used to examine various types of wood for the presence of chelators. Western red cedar wood, Thuja plicata, was observed to contain large amounts of three substances that in low concentration would serve as chelators for S. typhimurium. The chelators from T. plicata were characterized and found to be alpha-, beta-, and gamma-thujaplicin. Other planar cyclic alpha-hydroxyketones were examined, and several were found to function as chelators for S. typhimurium.
摘要
鼠伤寒沙门氏菌菌株无法合成其正常的铁转运剂肠杆菌素，且在某些培养基上必须依靠外源性螯合剂（铁载体）才能生长，利用这些菌株检测了各类木材中螯合剂的存在情况。观察发现，西部红雪松（学名：北美乔柏）含有大量三种物质，这些物质在低浓度时可作为鼠伤寒沙门氏菌的螯合剂。对北美乔柏中的螯合剂进行了表征，发现它们是α-、β-和γ-土荆芥素。还检测了其他平面环状α-羟基酮，发现其中几种可作为鼠伤寒沙门氏菌的螯合剂。
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