在肝脏乙醇脱氢酶催化反式-4-(N,N-二甲基氨基)肉桂醛还原反应中，氢化物转移先于质子转移的证据。 - Suppr

Suppr

超能文献

Evidence that hydride transfer precedes proton transfer in the liver alcohol dehydrogenase catalyzed reduction of trans-4-(N,N-dimethylamino)cinnamaldehyde.

作者信息

Morris R G, Saliman G, Dunn M F

出版信息

Biochemistry. 1980 Feb 19;19(4):725-31. doi: 10.1021/bi00545a018.

DOI:10.1021/bi00545a018

PMID:6986906

Abstract

摘要

相似文献

Evidence that hydride transfer precedes proton transfer in the liver alcohol dehydrogenase catalyzed reduction of trans-4-(N,N-dimethylamino)cinnamaldehyde.在肝脏乙醇脱氢酶催化反式-4-(N,N-二甲基氨基)肉桂醛还原反应中，氢化物转移先于质子转移的证据。

Biochemistry. 1980 Feb 19;19(4):725-31. doi: 10.1021/bi00545a018.

Reaction of 4-trans-(N,N-dimethylamino)cinnamaldehyde with the liver alcohol dehydrogenase-oxidized nicotinamide adenine dinucleotide complex.4-反式-（N，N-二甲基氨基）肉桂醛与肝脏乙醇脱氢酶-氧化型烟酰胺腺嘌呤二核苷酸复合物的反应

Biochemistry. 1984 Aug 28;23(18):4094-100. doi: 10.1021/bi00313a013.

Active-site-specific reconstituted cobalt(II) horse-liver alcohol dehydrogenase. Changes of the spectra of the substrate trans-4-(N,N-dimethylamino)-cinnamaldehyde and of the catalytic cobalt ion upon ternary complex formation with NADH and 1,4,5,6-tetrahydronicotinamide--adenine dinucleotide.

Eur J Biochem. 1979 Oct;100(1):267-70. doi: 10.1111/j.1432-1033.1979.tb02057.x.

Carboxymethylated liver alcohol dehydrogenase: kinetic and thermodynamic characterization of reactions with substrates and inhibitors.羧甲基化肝脏乙醇脱氢酶：与底物及抑制剂反应的动力学和热力学特性

Biochemistry. 1984 Dec 18;23(26):6829-39. doi: 10.1021/bi00321a085.

Influence of coenzyme structure on the transient chemical intermediate formed during horse-liver alcohol-dehydrogenase-catalyzed reduction of aromatic aldehydes.辅酶结构对马肝醇脱氢酶催化芳香醛还原过程中形成的瞬态化学中间体的影响。

Biochim Biophys Acta. 1986 Feb 14;869(3):265-74. doi: 10.1016/0167-4838(86)90066-x.

Roles of zinc ion and reduced coenzyme in the formation of a transient chemical intermediate during the equine liver alcohol dehydrogenase catalyzed reduction of an aromatic aldehyde.锌离子和还原型辅酶在马肝乙醇脱氢酶催化芳香醛还原过程中形成瞬态化学中间体的作用。

Biochemistry. 1973 Nov 20;12(24):4882-92. doi: 10.1021/bi00748a012.

Crystal structure determinations of coenzyme analogue and substrate complexes of liver alcohol dehydrogenase: binding of 1,4,5,6-tetrahydronicotinamide adenine dinucleotide and trans-4-(N,N-dimethylamino)cinnamaldehyde to the enzyme.

Biochemistry. 1982 Sep 28;21(20):4895-908. doi: 10.1021/bi00263a011.

Substituent effects on the ionization step regulating desorption and catalytic oxidation of alcohols bound to liver alcohol dehydrogenase.取代基对调节与肝脏乙醇脱氢酶结合的醇类脱附和催化氧化的电离步骤的影响。

Eur J Biochem. 1981 Mar;114(3):555-63. doi: 10.1111/j.1432-1033.1981.tb05180.x.

Unified mechanism for proton-transfer reactions affecting the catalytic activity of liver alcohol dehydrogenase.影响肝脏乙醇脱氢酶催化活性的质子转移反应的统一机制。

Eur J Biochem. 1980 Feb;103(3):565-75. doi: 10.1111/j.1432-1033.1980.tb05981.x.

Electronic substituent effects during the liver alcohol dehydrogenase catalyzed reduction of aromatic aldehydes.

Biochemistry. 1974 Jan 1;13(1):60-4. doi: 10.1021/bi00698a010.

引用本文的文献

Effects of high pressure on solvent isotope effects of yeast alcohol dehydrogenase.高压对酵母乙醇脱氢酶溶剂同位素效应的影响。

Biophys J. 2000 Sep;79(3):1621-8. doi: 10.1016/S0006-3495(00)76412-5.

Thermoanaerobacter brockii alcohol dehydrogenase: characterization of the active site metal and its ligand amino acids.嗜热栖热放线菌乙醇脱氢酶：活性位点金属及其配体氨基酸的表征

Protein Sci. 1997 Feb;6(2):450-8. doi: 10.1002/pro.5560060223.

Neutral metal-bound water is the base catalyst in liver alcohol dehydrogenase.与金属结合的中性水是肝脏乙醇脱氢酶中的碱性催化剂。

Proc Natl Acad Sci U S A. 1983 May;80(9):2584-8. doi: 10.1073/pnas.80.9.2584.

Reactions of electron-transfer flavoprotein and electron-transfer flavoprotein: ubiquinone oxidoreductase.电子传递黄素蛋白和电子传递黄素蛋白：泛醌氧化还原酶的反应。

Biochem J. 1987 Feb 1;241(3):883-92. doi: 10.1042/bj2410883.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验