Ayoub G, Park M S, Terasaki P I, Iwaki Y, Opelz G
Transplantation. 1980 Mar;29(3):227-9. doi: 10.1097/00007890-198003000-00013.
Over 200 cadaver donor transplants were crossmatched against T and B lymphocytes at 5 and 37 C. Of 54 positive B cell crossmatches, one-half had cold antibodies and one-half had warm antibodies. The 1-year transplant survival was 58% for B-cold-positive crossmatches and 42% for B-warm-positive crossmatches. The B-warm-positive crossmatches, when subdivided into those with strong HLA-DR antibodies showed a 27% 1-year transplant survival rate. We conclude that B cell-positive crossmatches with HLA-DR antibodies are deleterious and that those with cold anti-IgM antibodies may enhance graft survival.
超过200例尸体供体移植器官与T淋巴细胞和B淋巴细胞在5℃和37℃下进行了交叉配型。在54例阳性B细胞交叉配型中，一半有冷抗体，一半有温抗体。B细胞冷抗体阳性交叉配型的1年移植存活率为58%，B细胞温抗体阳性交叉配型的为42%。B细胞温抗体阳性交叉配型再细分为具有强HLA - DR抗体的交叉配型，其1年移植存活率为27%。我们得出结论，具有HLA - DR抗体的B细胞阳性交叉配型是有害的，而具有冷抗IgM抗体的交叉配型可能提高移植物存活率。
