只有B淋巴细胞可诱导大鼠心脏同种异体移植的主动增强。
Only B lymphocytes induce active enhancement of rat cardiac allografts.
作者信息
Lauchart W, Alkins B J, Davies D A
出版信息
Transplantation. 1980 Mar;29(3):259-61. doi: 10.1097/00007890-198003000-00020.
LEW rats were immunized 7 days before (LEW X BN)F1 heart transplantation with 10(7) BN donor cells, either purified erythrocytes (RBC), peripheral blood (PBL), splenic, nylon-wool-adherent (B-enriched) or nylon-wool-nonadherent (T-enriched) lymphocytes. Allograft rejection was only significantly enhanced in animals pretreated with lymphocyte populations containing surface immunoglobulin (SIgG)-positive cells (PBL, splenic, or B-enriched lymphocytes). Recipients immunized with RBC or T-enriched lymphocytes containing few, if any, SIgG-bearing B lymphocytes showed no significant graft prolongation.
在（LEW×BN）F1心脏移植前7天，用10⁷个BN供体细胞对LEW大鼠进行免疫，这些供体细胞为纯化红细胞（RBC）、外周血（PBL）、脾脏、尼龙毛黏附（富含B细胞）或尼龙毛非黏附（富含T细胞）淋巴细胞。仅在预先用含有表面免疫球蛋白（SIgG）阳性细胞的淋巴细胞群体（PBL、脾脏或富含B细胞的淋巴细胞）处理的动物中，同种异体移植排斥反应才显著增强。用几乎不含或不含携带SIgG的B淋巴细胞的RBC或富含T细胞的淋巴细胞免疫的受体，其移植物存活时间没有显著延长。
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