Wald N, Cuckle H, Stirrat G M, Bennett M J, Turnbull A C
Lancet. 1977 Aug 6;2(8032):268-70. doi: 10.1016/s0140-6736(77)90953-9.
High maternal serum-alpha-fetoprotein (A.F.P.) concentrations in the first half of pregnancy were associated with prematurity and high perinatal mortality. 94 singleton pregnancies without neural-tube defects but with A.F.P. levels equal to or greater than three times the normal median resulted in the birth of infants weighing, on average, 357 g less than controls (P less than 0-001). The mean head circumference of the infants was also smaller than that of the controls. The 1 stillbirth and 3 neonatal deaths yielded a mortality-rate more than three and a half times that for singleton births without neural-tube defects at the same hospital in the years 1974-76. The results suggest that some pregnant women who will deliver low-birth-weight infants at high risk of perinatal death may be identified by means of serum-A.F.P. measurement early in pregnancy.
孕期前半期孕妇血清甲胎蛋白（A.F.P.）浓度升高与早产及高围产期死亡率相关。94例单胎妊娠，无神经管缺陷但A.F.P.水平等于或高于正常中位数3倍，所产婴儿平均体重比对照组轻357克（P小于0.001）。这些婴儿的平均头围也小于对照组。1例死产和3例新生儿死亡导致的死亡率比1974 - 1976年同一家医院无神经管缺陷的单胎分娩死亡率高出三倍半以上。结果表明，通过孕期早期测量血清A.F.P.，可能识别出一些将分娩低体重婴儿且围产期死亡风险高的孕妇。
