Eiseman B, Hansbrough J, Weil R
Am Surg. 1980 Jan;46(1):24-7.
New approaches for experimental immunosuppression have been reviewed. These include the following: 1) cyclosporin A, a metabolite from fungus that suppresses multiplying but not resting T and B lymphocytes and can be used in pulsed manner with interspersed drug-free periods; 2) total lymphoid irradiation (transplantation tolerance in rats has been achieved by pretransplant radiation); 3) thoracic duct drainage, which is being revived following its demonstrated effectiveness in the treatment of some autoimmune disease; 4) hyperbaric oxygen (HBOX). We have found that HBOX 2 1/2 ATA for five hours daily depresses cell-mediated immunity in mice and that this can be reversed by intravenous administration of autologous macrophages.
对实验性免疫抑制的新方法进行了综述。这些方法包括：1）环孢素A，一种来自真菌的代谢产物，可抑制增殖的而非静止的T和B淋巴细胞，并且可以以脉冲方式使用，期间穿插无药期；2）全淋巴照射（通过移植前辐射已在大鼠中实现移植耐受性）；3）胸导管引流，在证明其对某些自身免疫性疾病的治疗有效后，该方法正在复兴；4）高压氧（HBOX）。我们发现，每天以2.5个绝对大气压（ATA）的压力进行5小时的高压氧治疗会抑制小鼠的细胞介导免疫，并且静脉注射自体巨噬细胞可逆转这种抑制作用。
