Joss R, Goldhirsch A, Brunner K
Schweiz Med Wochenschr. 1980 Mar 15;110(11):390-404.
This review deals with renal and urinary tract complications in tumor patients. Neoplastic infiltration of the kidney and glomerular nephropathies in neoplastic diseases are discussed. Tumor obstruction of the urinary tract and renal disease due to tumor metabolites are important, potentially reversible complications. Radiation nephritis and drug-induced renal disease can often be avoided with the aid of precautionary measures. Urogenital infections in tumor patients are frequent and often due to atypical microorganisms. Guidelines for dosage modifications of antineoplastic agents in patients with renal insufficiency are summarized. Renal failure in tumor patients deserves a careful diagnostic and therapeutic approach. The potential renal and urinary tract toxicities of the different therapeutic modalities must be considered when planning therapy for cancer patients.
本综述涉及肿瘤患者的肾脏和尿路并发症。讨论了肿瘤对肾脏的浸润以及肿瘤疾病中的肾小球肾病。尿路肿瘤梗阻和肿瘤代谢产物所致肾病是重要的、潜在可逆转的并发症。借助预防措施,放射性肾炎和药物性肾病通常可以避免。肿瘤患者的泌尿生殖系统感染很常见,且往往由非典型微生物引起。总结了肾功能不全患者抗肿瘤药物剂量调整的指南。肿瘤患者的肾衰竭值得采取谨慎的诊断和治疗方法。在为癌症患者规划治疗方案时,必须考虑不同治疗方式潜在的肾脏和尿路毒性。