清醒犬肾前列腺素E、肾素与肾血管张力之间的相互关系
Interrelationship between renal prostaglandin E, renin, and renal vascular tone in conscious dogs.
作者信息
Zimmerman B G, Mommsen C, Kraft E
出版信息
Adv Prostaglandin Thromboxane Res. 1980;7:1153-7.
PGSI cause renal vasoconstriction in furosemide- and low-salt-treated dogs, but not in untreated normotensive dogs, and this effect is closely related to their control PRA. PGSI cause a lesser degree of renal vasoconstriction in 2-kidney 1-clip Goldblatt hypertensive dogs which does not correlate with their control PRA. PGSI abolish PG modulation of the renin-angiotensin system, and this effect appears to account for the increased renal vascular tone induced in furosemide- and low-salt-treated dogs.
前列腺素合成抑制剂（PGSI）在速尿和低盐处理的犬中会引起肾血管收缩，但在未经处理的正常血压犬中则不会，且这种作用与其对照的血浆肾素活性（PRA）密切相关。PGSI在两肾一夹型Goldblatt高血压犬中引起的肾血管收缩程度较小，且这与它们对照的PRA不相关。PGSI消除了前列腺素对肾素-血管紧张素系统的调节作用，且这种作用似乎是速尿和低盐处理犬中肾血管张力增加的原因。
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