前列腺素F2α刺激离体灌注大鼠心脏中前列腺素E2和前列环素的释放。
PGF2 alpha stimulates release of PGE2 and PGI2 in the isolated perfused rat heart.
作者信息
de Deckere E A, ten Hoor F
出版信息
Adv Prostaglandin Thromboxane Res. 1980;7:655-8.
PMID:6989193
Abstract
The effect of prostaglandin F2 alpha on the release of PGI2 and PGE2 was investigated in isolated perfused rat heart. PGF2 alpha at concentrations of 1.7 nmoles liter-1 or higher increased the release of PGI2 and PGE2 alpha. The release of PGI2 was highest after 3 to 4 min of perfusion with PGF2 alpha. This phenomenon may be of physiological significance and might explain the observed variable effects of PGF2 alpha on vascular resistance.
摘要
在离体灌注大鼠心脏中研究了前列腺素F2α对前列环素（PGI2）和前列腺素E2（PGE2）释放的影响。浓度为1.7纳摩尔/升或更高的PGF2α可增加PGI2和PGE2的释放。在用PGF2α灌注3至4分钟后，PGI2的释放量最高。这种现象可能具有生理意义，并且可能解释了观察到的PGF2α对血管阻力的不同作用。
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