Hamod K A, Spence M R, Rosenshein N B, Dillon M B
Am J Obstet Gynecol. 1980 Apr 15;136(8):976-9. doi: 10.1016/0002-9378(80)90620-1.
A total of 79 patients underwent vaginal hysterectomy and were randomly assigned to three regimens of prophylactic antibiotics: multidose intravenous sodium cephalothin, single-dose intravenous sodium cephalothin, and single-dose oral metronidazole. Control groups were selected from two previous studies conducted at our institution. The incidence rates of infectious morbidity following all three regimens of antibiotics were substantially lower than in the control groups. There was no statistically significant difference in the incidence of standard febrile morbidity and serious pelvic infections among the three groups. The fever index was lowest in the single-dose sodium cephalothin group.
共有79例患者接受了阴道子宫切除术，并被随机分配到三种预防性抗生素治疗方案中：多剂量静脉注射头孢噻吩钠、单剂量静脉注射头孢噻吩钠和单剂量口服甲硝唑。对照组选自本机构之前进行的两项研究。所有三种抗生素治疗方案后的感染发病率均显著低于对照组。三组之间标准发热发病率和严重盆腔感染的发生率没有统计学上的显著差异。单剂量头孢噻吩钠组的发热指数最低。
