Heffner R R, Barron S A
Arch Pathol Lab Med. 1980 May;104(5):261-4.
Focal myositis is a benign pseudotumor of skeletal muscle, the cause of which is obscure. It usually appears as a steadily enlarging mass within the muscle of an extremity. The pathologic features are those of an inflammatory myopathy in which lymphocytic infiltrates, muscle cell necrosis, and regeneration are seen. Four cases of focal myositis were studied using enzyme histochemistry and electron microscopy. The changes of denervation atrophy, reinnervation, and fiber hypertrophy were found. Intramuscular nerve damage manifested by axonal swelling, demyelination, and endoneurial fibrosis was evident. The findings suggest that a denervating process plays an important role in the pathogenesis of focal myositis.
局灶性肌炎是一种骨骼肌的良性假瘤，其病因尚不清楚。它通常表现为四肢肌肉内持续增大的肿块。病理特征为炎性肌病，可见淋巴细胞浸润、肌细胞坏死和再生。利用酶组织化学和电子显微镜对4例局灶性肌炎进行了研究。发现了失神经萎缩、再支配和纤维肥大的变化。轴突肿胀、脱髓鞘和神经内膜纤维化所表现的肌内神经损伤很明显。这些发现提示失神经过程在局灶性肌炎的发病机制中起重要作用。
