Keating M J, Smith T L, Gehan E A, McCredie K B, Bodey G P, Spitzer G, Hersh E, Gutterman J, Freireich E J
Cancer. 1980 Apr 15;45(8):2017-29. doi: 10.1002/1097-0142(19800415)45:8<2017::aid-cncr2820450806>3.0.co;2-c.
Two hundred and two adult patients with acute leukemia were analyzed to determine pretreatment and treatment factors that could predict for duration of bone marrow remission. Several factors had a significant effect on remission duration, including morphologic diagnosis (AML greater than ALL greater than AUL), initial blast cell count, age, serum LDH, fibrinogen level, labeling index, and in vitro agar colony growth. Patients who attained a remission quickly or in whom leukemic cells in blood and bone marrow were rapidly cleared had long remissions. After applying regression model fitting methods, the six major factors, in order of significance, were the initial serum LDH level, pretreatment fibrinogen level, the number of courses of treatment to obtain a remission, morphologic diagnosis, the halving rate of leukemic cells in the blood, and the age of the patient. The model derived from this study was applied to the 202 patients and suggested that patients likely to have short or long bone marrow remission can be identified.
对202例成年急性白血病患者进行分析，以确定可预测骨髓缓解持续时间的预处理和治疗因素。几个因素对缓解持续时间有显著影响，包括形态学诊断（急性髓系白血病大于急性淋巴细胞白血病大于急性未分化白血病）、初始原始细胞计数、年龄、血清乳酸脱氢酶、纤维蛋白原水平、标记指数和体外琼脂集落生长。迅速获得缓解或血液和骨髓中的白血病细胞迅速清除的患者缓解期长。应用回归模型拟合方法后，按重要性排序的六个主要因素为初始血清乳酸脱氢酶水平、预处理纤维蛋白原水平、获得缓解所需的疗程数、形态学诊断、血液中白血病细胞的减半率和患者年龄。本研究得出的模型应用于这202例患者，提示可以识别出可能有短或长骨髓缓解期的患者。
