Kimura N T, Taniguchi S, Aoki K, Baba T
Cancer Res. 1980 Jun;40(6):2061-8.
A strain of domestic bacteria, Bifidobacterium bifidum (Lac B), which is nonpathogenic and anerobic, selectively localized and proliferated in several types of mouse tumors following i.v. administration. None of the same bacilli could be detected in the tissues of healthy organs such as the liver, spleen, kidney, lung, blood, bone marrow, and muscle 48 or 96 hr after i.v. administration into tumor-bearing mice. Proliferation of Lac B in the tumor was artifically stimulated by i.p. administration of DDD-H-2s mice of a synthesized disaccharide, lactulose (4-O-beta-D-galactopyranosyl-D-fructofuranose), a sugar which is not metabolized by mammalian tissue cells. Lac B, which survices and proliferates selectively in the tumor following i.v. administration into the tumor-bearing host, should aid in diagnosis and selective therapy for cancer.
一种国内菌株，双歧双歧杆菌（Lac B），它无致病性且厌氧，在静脉注射后能在几种类型的小鼠肿瘤中选择性地定位并增殖。给荷瘤小鼠静脉注射后48或96小时，在肝脏、脾脏、肾脏、肺、血液、骨髓和肌肉等健康器官的组织中均未检测到相同的杆菌。通过腹腔注射合成二糖乳果糖（4-O-β-D-吡喃半乳糖基-D-呋喃果糖）对DDD-H-2s小鼠进行人工刺激，可促进Lac B在肿瘤中的增殖，乳果糖是一种哺乳动物组织细胞不能代谢的糖。Lac B在静脉注射到荷瘤宿主后能在肿瘤中选择性存活和增殖，这应该有助于癌症的诊断和选择性治疗。
