从刺毛鼠（埃及刺毛鼠）分离出的胰岛的延迟或双相葡萄糖诱导胰岛素分泌：与动物年龄的关系。
Delayed or biphasic glucose-induced insulin secretion of pancreatic islets isolated from spiny mice (Acomys cahirinus) : relation to age of animals.
作者信息
Butter R, Keilacker H, Heinke P, Kloting I, Hahn H J
出版信息
Diabete Metab. 1980 Mar;6(1):47-9.
The dynamics of insulin release from spiny mouse perifused pancreatic islets was investigated. In agreement with earlier studies we found no initial (0-10 min) insulin secretion in response to glucose in islets prepared from mice up to 35 weeks of age. The islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile. The results suggest that immediate glucose response is modified by environmental or other factors related to age.
研究了多刺小鼠经外周灌注的胰岛释放胰岛素的动力学。与早期研究一致，我们发现，在35周龄以下小鼠制备的胰岛中，对葡萄糖刺激没有初始（0-10分钟）胰岛素分泌。然而，40周龄以上动物的胰岛具有更高的胰岛素含量，并恢复了典型的双相胰岛素分泌模式。结果表明，即时葡萄糖反应受到与年龄相关的环境或其他因素的影响。
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