Delayed or biphasic glucose-induced insulin secretion of pancreatic islets isolated from spiny mice (Acomys cahirinus) : relation to age of animals.

The dynamics of insulin release from spiny mouse perifused pancreatic islets was investigated. In agreement with earlier studies we found no initial (0-10 min) insulin secretion in response to glucose in islets prepared from mice up to 35 weeks of age. The islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile. The results suggest that immediate glucose response is modified by environmental or other factors related to age.