van Soeren F
J Int Med Res. 1980;8(2):132-5. doi: 10.1177/030006058000800205.
In an open two-period crossover study hydrochlorothiazide/amiloride and chlorthalidone were compared with regard to their anti-hypertensive and biochemical properties in ambulatory patients with mild to moderate hypertension. Twenty-five out of twenty-six patients completed the study. In the chlorthalidone group plasma potassium was consistently lower than in the hydrochlorothiazide/amiloride group, the difference achieved significance at 8 and 12 weeks after the start of treatment. With regard to the hypertension and other parameters no statistically significant differences were found.
在一项开放性两阶段交叉研究中，对氢氯噻嗪/阿米洛利和氯噻酮在轻度至中度高血压门诊患者中的降压及生化特性进行了比较。26名患者中有25名完成了研究。氯噻酮组的血浆钾始终低于氢氯噻嗪/阿米洛利组，在治疗开始后的第8周和第12周，这种差异具有统计学意义。在高血压及其他参数方面，未发现统计学上的显著差异。
