Brook I
J Pediatr. 1980 Jun;96(6):1000-4. doi: 10.1016/s0022-3476(80)80625-1.
Seventy-four transtracheal aspirations and expectorated sputum specimens were collected from a number of children with aspiration pneumonia. The aspirates were cultured for aerobic and anaerobic bacteria. Cultures obtained through TTA contained fewer pathogens than in cultures of expectorated sputum. Gram stains of TTA aspirates offered prompt presumptive bacteriologic diagnosis in 93% of patients, whereas Gram stains of expectorated sputum were not specific. The recovery of Gram-negative enteric rods in the TTA aspirate provided guidance in adding an aminoglycoside to the antimicrobial therapy in 35 children (47%). Side effects of TTA included mild hemoptysis and, in rare instances, subcutaneous emphysema. We found TTA to be a generally safe and useful procedure in the diagnosis and therapy of aspiration pneumonia in children.
从一些患有吸入性肺炎的儿童中收集了74份经气管抽吸物和咳出的痰液标本。对抽吸物进行需氧菌和厌氧菌培养。通过经气管抽吸(TTA)获得的培养物中病原体比咳出痰液的培养物少。TTA抽吸物的革兰氏染色在93%的患者中提供了快速的初步细菌学诊断,而咳出痰液的革兰氏染色不具有特异性。TTA抽吸物中革兰氏阴性肠道杆菌的检出为35名儿童(47%)的抗菌治疗中添加氨基糖苷类药物提供了指导。TTA的副作用包括轻度咯血,在罕见情况下会出现皮下气肿。我们发现TTA在儿童吸入性肺炎的诊断和治疗中是一种总体安全且有用的方法。