Gillies A, Morgan T, Myers J
Med J Aust. 1980 Feb 23;1(4):170-2.
Piretanide, a diuretic that acts on the loop of Henle, was used to treat patients with cardiac failure. Over a three-day period it caused a significant dose related diuresis and weight loss. It was as effective as chlorothiazide in the control of cardiac failure and was well tolerated by the patients. Potassium loss was less than occurred with chlorothiazide. Its role in the treatment of cardiac failure requires further study and warrants further investigation. The study also showed that many patients with cardiac failure receive diuretic drugs which are not necessary.
吡咯他尼是一种作用于髓袢的利尿剂，曾用于治疗心力衰竭患者。在三天的时间里，它引起了显著的剂量相关利尿作用和体重减轻。在控制心力衰竭方面，它与氯噻嗪一样有效，并且患者耐受性良好。钾流失比氯噻嗪引起的要少。其在心力衰竭治疗中的作用需要进一步研究并值得深入调查。该研究还表明，许多心力衰竭患者服用了不必要的利尿药物。
