Withrow C D
Adv Neurol. 1980;27:635-42.
Although the ketogenic diet has been used in the therapy for epilepsy for more than 50 years, there are few studies concerned with the effects of this diet on the central nervous system. Recent attempts to unravel the biochemical effects of the ketogenic diet on the brain seem to be a fruitful approach to understanding how the ketogenic diet causes anticonvulsant effects. Another exciting approach is the development of animal models in which various effects of the diet can be correlated with changes in seizure protection. It would be useful to determine whether the diet produces any neurophysiological effects that could account for some, or all, of its antiseizure properties. Finally, the efficacy of the diet is impressive. It is likely that the ketogenic diet will never be of major therapeutic importance because of the expense and commitment required of the patient and the family. Nevertheless, it appears obvious that continued study of a therapy which seems to work so well will give us some valuable clues as to the mechanism of seizures and their control. Further investigations into the mechanism of action of the ketogenic diet should be encouraged.
尽管生酮饮食用于癫痫治疗已有50多年，但很少有研究关注这种饮食对中枢神经系统的影响。最近试图揭示生酮饮食对大脑的生化作用，似乎是理解生酮饮食如何产生抗惊厥作用的有效途径。另一个令人兴奋的方法是开发动物模型，在该模型中饮食的各种作用可与癫痫保护的变化相关联。确定该饮食是否产生任何可解释其部分或全部抗癫痫特性的神经生理作用将很有用。最后，该饮食的疗效令人印象深刻。由于患者及其家庭所需的费用和投入，生酮饮食可能永远不会具有主要的治疗重要性。然而，显然对一种似乎效果良好的疗法继续进行研究，将为我们提供有关癫痫发作及其控制机制的一些有价值的线索。应鼓励对生酮饮食的作用机制进行进一步研究。
