翻译起始因子2改变大肠杆菌核糖核酸聚合酶的转录选择性。
Translation initiation factor 2 alters transcriptional selectivity of Escherichia coli ribonucleic acid polymerase.
作者信息
Travers A A, Debenham P G, Pongs O
出版信息
Biochemistry. 1980 Apr 15;19(8):1651-6. doi: 10.1021/bi00549a020.
PMID:6990978
Abstract
Preparations of translation initiation factor IF-2 strongly stimulate the production of rRNA by Escherichia coli RNA polymerase but have little effect on the synthesis of other RNA species. The factor alters the sedimentation characteristics of RNA polymerase holoenzyme. We suggest a mechanism by which IF-2 alters the pattern of transcriptional selectivity of RNA polymerase.
摘要
翻译起始因子IF-2的制剂能强烈刺激大肠杆菌RNA聚合酶产生rRNA，但对其他RNA种类的合成影响很小。该因子改变了RNA聚合酶全酶的沉降特性。我们提出了一种IF-2改变RNA聚合酶转录选择性模式的机制。
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