Briner J, Binswanger U, Largiadèr F
Clin Nephrol. 1980 Apr;13(4):189-96.
Significant glomerular changes occur in a substantial number of renal cadaver allotransplants. Transplant glomerulopathy and recurrent glomerulonephritis account for most of the lesions whereas the development of de novo glomerulonephritis is a rare event. Only a few cases of membranous glomerulonephritis in the graft have been documented. The four patients presented all developed heavy proteinuria of 11.5 to 14 g/day 5 months to 1 year after transplantation. Three cases of de novo membranous glomerulonephritis were transplanted because of renal failure due to chronic pyelonephritis, chronic glomerulonephritis and medullary sponge kidney. One patient has recurrent membranous glomerulonephritis. Transplant biopsy revealed only minimal glomerular changes by light microscopy in all cases. Immunofluorescence and electron microscopy demonstrated typical membranous glomerulonephritis.
大量肾移植尸体供肾中出现了显著的肾小球改变。移植性肾小球病和复发性肾小球肾炎是大多数病变的原因，而新发肾小球肾炎的发生则是罕见事件。仅有少数移植肾发生膜性肾小球肾炎的病例被记录。所报告的这4例患者在移植后5个月至1年均出现了每日11.5至14克的大量蛋白尿。3例新发膜性肾小球肾炎患者因慢性肾盂肾炎、慢性肾小球肾炎和髓质海绵肾导致的肾衰竭而接受了移植。1例患者患有复发性膜性肾小球肾炎。所有病例的移植肾活检在光镜下仅显示轻微的肾小球改变。免疫荧光和电子显微镜检查显示为典型的膜性肾小球肾炎。
