乙酰苯丙氨酰赖氨酸氯甲基酮的合成、结晶及性质：一种潜在的丝氨酸蛋白酶抑制剂
Synthesis, crystallization and properties of acetyl phenylalanyl lysine chloromethyl ketone: a potential inhibitor of serine proteases.
作者信息
Murthy V V, Laster T
出版信息
Experientia. 1980 Apr 15;36(4):397-8. doi: 10.1007/BF01975108.
PMID:6991271
Abstract
A procedure for the synthesis of acetyl phenylalanyl lysine chloromethyl ketone is described. The chloromethyl ketone derivative is a noncompetitive inhibitor of trypsin (Ki = 5.9 x 10(-3) M).
摘要
描述了一种合成乙酰苯丙氨酰赖氨酸氯甲基酮的方法。该氯甲基酮衍生物是胰蛋白酶的非竞争性抑制剂（Ki = 5.9×10⁻³ M）。
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