Solomon S S, Duckworth W C, Jallepalli P, Bobal M A, Iyer R
Diabetes. 1980 Jan;29(1):22-6. doi: 10.2337/diab.29.1.22.
Patients with acute pancreatitis were studied by arginine infusion at 48--72 h. 7--10 days, and 18--21 days after onset of their illness. Plasma glucose, insulin, and glucagon values were determined. Acute pancreatitis was characterized by fasting hyperglycemia and hyperglucagonemia, associated with relative hyoinsulinemia. Arginine stimulation early in the disease (48--72 h) demonstrated hyperglycemia and hyperglucagonemia, which normalized by 18--21 days. Both phases of the normal biphasic insulin response to arginine were decreased during the initial arginine infusion. By 18--21 days, although the first phase was completely normal, the second phase of insulin secretion remained depressed. Acute pancreatitis is associated with damage to both the endocrine and exocrine pancreas. Glucose intolerance seen with this disease appears to be the result of hyperglucagonemia and relative hypoinsulinemia. Although the healing process at 3 wk is associated with return of plasma glucose and glucagon concentrations to normal, the impaired second phase insulin secretion persists.
在急性胰腺炎患者发病后的48 - 72小时、7 - 10天以及18 - 21天，通过精氨酸输注对其进行研究。测定血浆葡萄糖、胰岛素和胰高血糖素值。急性胰腺炎的特征为空腹高血糖和高胰高血糖素血症，并伴有相对的低胰岛素血症。疾病早期（48 - 72小时）精氨酸刺激显示高血糖和高胰高血糖素血症，至18 - 21天时恢复正常。在最初输注精氨酸期间，正常的精氨酸双相胰岛素反应的两个阶段均降低。到18 - 21天时，虽然第一阶段完全正常，但胰岛素分泌的第二阶段仍受抑制。急性胰腺炎与内分泌胰腺和外分泌胰腺的损伤均有关。该疾病中出现的葡萄糖不耐受似乎是高胰高血糖素血症和相对低胰岛素血症的结果。虽然3周时的愈合过程伴随着血浆葡萄糖和胰高血糖素浓度恢复正常，但受损的第二阶段胰岛素分泌仍然持续存在。
