抗高血压药理学
Antihypertensive pharmacology.
作者信息
Gerber J G, Freed C R, Nies A S
出版信息
West J Med. 1980 May;132(5):430-9.
Abstract
Although drug treatment of hypertension is associated with improved survival and decreased vascular complications, drug compliance is a major problem in the control of hypertension. All antihypertensive medications are associated with side effects; thus, it is a physician's responsibility to explain to each patient the side effects of the drugs he prescribes to treat hypertension, and to instill in the patient a sense of necessity for the treatment of hypertension. The choice of antihypertensive drug should be made based on each patient's lifestyle, overall health and ability to tolerate the drug. Ideally, the antihypertensive regimen should be simple, effective, convenient to take and have very few side effects.
摘要
尽管高血压的药物治疗与生存率提高及血管并发症减少相关，但药物依从性是高血压控制中的一个主要问题。所有抗高血压药物都有副作用；因此，向每位患者解释其所开用于治疗高血压药物的副作用，并向患者灌输治疗高血压的必要性，是医生的责任。抗高血压药物的选择应基于每位患者的生活方式、整体健康状况以及耐受药物的能力。理想情况下，抗高血压治疗方案应简单、有效、服用方便且副作用极少。
相似文献
1
Antihypertensive pharmacology.抗高血压药理学
West J Med. 1980 May;132(5):430-9.
2
Applied pharmacology of anti-hypertensive drugs.抗高血压药物的应用药理学
Conn Med. 1976 Mar;40(3):169-74.
3
Drugs used in the treatment of hypertension.用于治疗高血压的药物。
Mod Concepts Cardiovasc Dis. 1973 Jul;42(7):33-6.
4
Drug treatment of hypertension.高血压的药物治疗
Compr Ther. 1977 May;3(5):34-46.
5
Anti-hypertensive drugs in the pregnant patient.孕妇使用的抗高血压药物。
Obstet Gynecol Surv. 1980 Apr;35(4):191-204. doi: 10.1097/00006254-198004000-00001.
6
Choice of antihypertensive drugs for the treatment of hypertension, including hypertensive emergencies.用于治疗高血压（包括高血压急症）的抗高血压药物的选择
Cardiovasc Clin. 1974;6(2):199-221.
7
Workup and treatment of the average hypertensive patient.普通高血压患者的检查与治疗
Compr Ther. 1978 Dec;4(12):40-5.
8
Management of systemic hypertension in children.儿童系统性高血压的管理
Pediatr Ann. 1982 Jul;11(7):604-5, 607-10, 612-3. doi: 10.3928/0090-4481-19820701-10.
9
Antihypertensive drugs: clinical pharmacology and therapeutic use.抗高血压药物：临床药理学与治疗应用。
Drugs. 1977 Dec;14(6):420-60. doi: 10.2165/00003495-197714060-00002.
10
The use of antihypertensive drugs in hypertension in pregnancy.抗高血压药物在妊娠期高血压中的应用。
Clin Obstet Gynaecol. 1977 Dec;4(3):685-705.
引用本文的文献
1
Design, synthesis and characterization of novel pyridazin-3-one derivatives: vasorelaxant activity and insights into eNOS modulation.新型哒嗪-3-酮衍生物的设计、合成与表征：血管舒张活性及对内皮型一氧化氮合酶调节的见解
RSC Med Chem. 2025 Jul 2. doi: 10.1039/d4md00998c.
2
Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues.强效血管舒张剂的合成：6-(4-取代苯基)-3-哒嗪酮衍生物作为潜在肼屈嗪类似物的计算机模拟和体外评价。
Sci Rep. 2024 Nov 27;14(1):29514. doi: 10.1038/s41598-024-79697-1.
3
Anti-Obesity Medications and Investigational Agents: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022.抗肥胖药物与研究性药物：肥胖医学协会（OMA）2022年临床实践声明（CPS）
Obes Pillars. 2022 Apr 15;2:100018. doi: 10.1016/j.obpill.2022.100018. eCollection 2022 Jun.
4
Effect of Central Corticotropin-Releasing Factor on Hepatic Lipid Metabolism and Inflammation-Related Gene Expression in Rats.中枢促肾上腺皮质释放因子对大鼠肝脂代谢及炎症相关基因表达的影响。
Int J Mol Sci. 2021 Apr 11;22(8):3940. doi: 10.3390/ijms22083940.
5
The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.乙酰水杨酸通过刺激肾皮质激素合成以及抑制一种高血压蛋白——皮肤杀菌肽亚型2的产生来诱导一氧化氮合成，从而在高血压正常化过程中的作用。
Int J Biomed Sci. 2014 Sep;10(3):158-66.
6
Hydralazine modifies Aβ fibril formation and prevents modification by lipids in vitro.肼屈嗪可修饰 Aβ 纤维形成并防止体外脂质修饰。
Biochemistry. 2010 Dec 14;49(49):10371-80. doi: 10.1021/bi101249p. Epub 2010 Nov 17.
本文引用的文献
1
Specificity of the transport system for neutral amino acids in the hamster intestine.仓鼠肠道中中性氨基酸转运系统的特异性
Am J Physiol. 1962 May;202:919-25. doi: 10.1152/ajplegacy.1962.202.5.919.
2
FLUID RETENTION PRODUCED BY GUANETHIDINE; CHANGES IN BODY EXCHANGEABLE SODIUM, BLOOD VOLUME, AND CREATININE CLEARANCE.胍乙啶引起的体液潴留；机体可交换钠、血容量及肌酐清除率的变化
Circulation. 1965 Apr;31:490-6. doi: 10.1161/01.cir.31.4.490.
3
INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS.胍乙啶与肾上腺素能神经元的相互作用。
J Pharmacol Exp Ther. 1965 Mar;147:303-12.
4
Depressive reactions in hypertensive patients; a comparison of those treated with Rauwolfia and those receiving no specific antihypertensive treatment.高血压患者的抑郁反应；萝芙木治疗组与未接受特定抗高血压治疗组的比较。
Circulation. 1959 Mar;19(3):366-75. doi: 10.1161/01.cir.19.3.366.
5
Edema and congestive failure related to administration of Rauwolfia serpentina.
J Am Med Assoc. 1955 Oct 1;159(5):439.
6
Cardiovascular actions of sodium nitroprusside in animals and hypertensive patients.
Circulation. 1955 Feb;11(2):188-98. doi: 10.1161/01.cir.11.2.188.
7
Clinical and experimental studies on the hydralazine syndrome and its relationship to systemic lupus erythematosus.关于肼苯哒嗪综合征及其与系统性红斑狼疮关系的临床与实验研究。
Medicine (Baltimore). 1967 Jan;46(1):1-33. doi: 10.1097/00005792-196701000-00001.
8
The paradox of beta-adrenergic blockade in hypertension.高血压中β-肾上腺素能阻滞剂的悖论。
Circulation. 1968 Mar;37(3):417-23. doi: 10.1161/01.cir.37.3.417.
9
The importance of the rapid administration of diazoxide in accelerated hypertension.
N Engl J Med. 1971 Sep 9;285(11):603-6. doi: 10.1056/NEJM197109092851104.
10
Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study.血压在中风中作用的流行病学评估。弗明汉姆研究。
JAMA. 1970 Oct 12;214(2):301-10.
Zotero 插件