Mascaro J M, Rozman C, Palou J, Grañena A, Castel T, Feliu E, Mallolas J
Br J Dermatol. 1980 Apr;102(4):461-6. doi: 10.1111/j.1365-2133.1980.tb06561.x.
The cutaneous changes of the acute form of graft-vs-host reaction are described in two patients who underwent bone marrow transplantation for treatment of severe aplastic anaemia. One patient went on to develop a chronic reaction of the lichenoid type. Histopathology confirmed the presence of 'satellite cell necrosis' from the acute stage of the disease onwards. Direct immunofluorescence showed deposits of immunoglobulin (IgG, IgM), fibrinogen and complement on the necrotic keratinocytes, whilst the basement membrane was positive for C3. These findings suggest that humoral immunity as well as cellular immunity may play a part in the production of the rash.
两名因严重再生障碍性贫血接受骨髓移植的患者出现了移植物抗宿主反应急性形式的皮肤变化。其中一名患者继而发展为苔藓样慢性反应。组织病理学证实从疾病急性期起就存在“卫星细胞坏死”。直接免疫荧光显示免疫球蛋白（IgG、IgM）、纤维蛋白原和补体沉积在坏死的角质形成细胞上，而基底膜C3呈阳性。这些发现表明体液免疫以及细胞免疫可能在皮疹的产生中起作用。
