自发性高血压大鼠的免疫抑制
Immunological depression in spontaneously hypertensive rats.
作者信息
Takeichi N, Suzuki K, Okayasu T, Kobayashi H
出版信息
Clin Exp Immunol. 1980 Apr;40(1):120-6.
Cell-mediated immunity was investigated in spontaneously hypertensive rats (SHR). The thymuses of young SHR rats before developing hypertension had reduced numbers of immature T lymphocytes which were detected by the rosette formation test with guinea-pig erythrocytes in the presence of foetal bovine serum, whereas the thymuses of eight other rat strains tested contained about 60% of rosetting cells. The number of rosetting cells decreased progressively with age. The blastogenic responses to PHA and Con A of the SHR rats' lymphocytes was depressed to less than one-fifth when compared to those of othe rat strains including W/7k rats, the original colony of the SHR rats. Eight-month-old SHR rats showed fewer mitogenic responses than those of 2-month-old SHR rats. Other cell-mediated immune responses, including delayed hypersensitivity, allograft rejections, and a co-operation of T and B lymphocytes to produce humoral antibody formation were depressed significantly when compared to those of other rat strains. Possible mechanisms of immunological depression in the SHR rats in relation to the devleopment of hypertension are discussed.
对自发性高血压大鼠（SHR）的细胞介导免疫进行了研究。在出现高血压之前，幼年SHR大鼠的胸腺中，通过在胎牛血清存在下用豚鼠红细胞进行花环形成试验检测到的未成熟T淋巴细胞数量减少，而测试的其他八种大鼠品系的胸腺中含有约60%的花环形成细胞。花环形成细胞的数量随年龄逐渐减少。与包括SHR大鼠原始种群W/7k大鼠在内的其他大鼠品系相比，SHR大鼠淋巴细胞对PHA和Con A的增殖反应降低到不到五分之一。8月龄的SHR大鼠比2月龄的SHR大鼠表现出更少的促有丝分裂反应。与其他大鼠品系相比，包括迟发型超敏反应、同种异体移植排斥反应以及T和B淋巴细胞协同产生体液抗体形成在内的其他细胞介导免疫反应均显著降低。讨论了SHR大鼠免疫抑制与高血压发展相关的可能机制。
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