Mngola E N
J Int Med Res. 1980;8(3):199-204. doi: 10.1177/030006058000800304.
The effects of placebo and of a spironolactone-althiazide combination in the treatment of twenty-two Kenyan Africans with hypertension were assessed using a double-blind technique. After a 2-week medication-free period, patients were randomly allocated to placebo or active treatment for 6 weeks then crossing over to the alternative medication for a further 6 weeks, reverting to the original medication for a final 6 weeks. 100 mg spironolactone plus 60 mg althiazide per day was found to produce greater falls in blood pressure when compared with the placebo periods, sometimes significantly. No serious side-effects were reported. Electrolytes remained within normal limits.
采用双盲技术评估了安慰剂和螺内酯-氢氯噻嗪组合对22名肯尼亚高血压非洲患者的治疗效果。在为期2周的无药期后，患者被随机分配接受安慰剂或积极治疗6周，然后交叉接受另一种药物治疗6周，最后再恢复使用原始药物治疗6周。结果发现，与使用安慰剂期间相比，每天服用100毫克螺内酯加60毫克氢氯噻嗪能使血压有更大幅度下降，有时差异显著。未报告严重副作用。电解质水平保持在正常范围内。
