Ekelund M, Ahrén B, Håkanson R, Lundquist I, Sundler F
Histochemistry. 1980;66(1):1-9. doi: 10.1007/BF00493240.
Quinacrine is a fluorescent anti-malarial acridine derivative which binds selectively to a population of nerves, presumably peptidergic, and to certain peptide hormone-producing cells. Among these cells are glycopeptide hormone-producing cells in the adenohypophysis, the calcitonin cells in the thyroid, the insulin, glucagon and PP cells in the pancreatic islets, and the gastrin cells in the pyloric antrum. Available evidence suggests that the fluorophore accumulates in the secretory granules. The half-life of the fluorescence varies from one cell type to another, from 6 h in the gastrin cells to 40 h in the insulin cells. It cannot be excluded that the half-life of the fluorescence reflects the turn-over rate of the secretory granules and that the disappearance rate of the fluorescence is dependent upon the secretory activity of the cell.
喹吖因是一种荧光抗疟吖啶衍生物，它能选择性地与一群神经（可能是肽能神经）以及某些产生肽类激素的细胞结合。这些细胞包括腺垂体中产生糖肽激素的细胞、甲状腺中的降钙素细胞、胰岛中的胰岛素、胰高血糖素和PP细胞，以及幽门窦中的胃泌素细胞。现有证据表明，荧光团积聚在分泌颗粒中。荧光的半衰期因细胞类型而异，胃泌素细胞中为6小时，胰岛素细胞中为40小时。不能排除荧光的半衰期反映了分泌颗粒的更新率，且荧光的消失率取决于细胞的分泌活性。
