El Kholy A, Fraser D W, Guirguis N, Wannamaker L W, Plikaytis B D, Zimmerman R A
J Infect Dis. 1980 Jun;141(6):759-71. doi: 10.1093/infdis/141.6.759.
A two-year controlled trial of benzathine penicillin G treatment of persons who acquired group A streptococci, identified by semimonthly throat cultures, was carried out in Egypt in 110 apparently normal families and 84 families with a child suspected of having rheumatic heart disease. Penicillin treatment was associated with a marked decrease in prevalence of the organism (19.0%-5.4%) and a modest decrease in introductions into families (0.79-0.54 single introductions per person per year) but no decrease in spread within nonrheumatic families. Results in suspected-rheumatic families were similar. It was concluded that the schedule of penicillin treatment used had a minimal effect on streptococcal spread and is unlikely to be an effective control tool. Spread within families was most intense in those episodes in which the household contacts were two to 14 years of age, the introducer had sought medical care, or the introducer ultimately carried the streptococcal strain for three or more months.
1988年在埃及对110个表面上正常的家庭和84个有疑似患风湿性心脏病儿童的家庭进行了一项为期两年的对照试验，这些家庭中的个体通过半月一次的咽拭子培养来确定是否感染A组链球菌，随后接受苄星青霉素G治疗。青霉素治疗与该病菌流行率显著下降（从19.0%降至5.4%）以及家庭中病菌传入率适度下降（从每人每年0.79次传入降至0.54次）相关，但在非风湿性家庭中病菌传播率没有下降。在疑似患风湿性心脏病的家庭中结果类似。得出的结论是，所采用的青霉素治疗方案对链球菌传播的影响极小，不太可能是一种有效的控制手段。在家庭接触者年龄为2至14岁、引入病菌者寻求过医疗护理或引入病菌者最终携带该链球菌菌株达三个月或更长时间的那些发病情况中，家庭内传播最为强烈。
