Yamashita K, Mieno M, Yamashita E
J Endocrinol. 1980 Mar;84(3):449-52. doi: 10.1677/joe.0.0840449.
Arginine-vasotocin (0.1 or 10 ng/kg body wt) was administered into the carotid artery of anaesthetized immature male dogs 3 h before the administration of a standard dose of luteinizing hormone releasing hormone (LH-RH, 5 microgram/kg body wt) into the same vessel. The rate of secretion of 17-oxosteroids by the testes in vivo served as an index of luteinizing hormone (LH) secretion. The administration of LH-RH into the carotid artery of control dogs which had been injected with isotonic saline caused a slight but definite increase in the secretion of testicular 17-oxosteroids. This effect of LH-RH on the testicular secretion of steroids was markedly reduced by pretreatment with arginine-vasotocin. However, the testicular response to the i.v. administration of human chorionic gonadotrophin (5 i.u./kg body wt) was unaffected by pretreatment with arginine-vasotocin (10 ng/kg body wt). These results indicate that in immature male dogs, arginine-vasotocin is able to inhibit the action of LH-RH by acting directly on the anterior pituitary gland.
在向麻醉的未成年雄性犬的同一血管内注射标准剂量的促黄体生成激素释放激素（LH-RH，5微克/千克体重）前3小时，将精氨酸加压催产素（0.1或10纳克/千克体重）注入其颈动脉。睾丸在体内分泌17-氧类固醇的速率作为促黄体生成素（LH）分泌的指标。向已注射等渗盐水的对照犬的颈动脉内注射LH-RH，导致睾丸17-氧类固醇的分泌略有但明显增加。精氨酸加压催产素预处理可显著降低LH-RH对睾丸类固醇分泌的这一作用。然而，精氨酸加压催产素（10纳克/千克体重）预处理不影响睾丸对静脉注射人绒毛膜促性腺激素（5国际单位/千克体重）的反应。这些结果表明，在未成年雄性犬中，精氨酸加压催产素能够通过直接作用于垂体前叶来抑制LH-RH的作用。
