Roth S H
J Rheumatol Suppl. 1980;6:68-75.
This multicenter clinical trial was conducted in patients with rheumatoid arthritis and osteoarthritis in an effort to evaluate and compare the efficacy and safety of benoxaprofen when taken as a single 600 mg dose in the evening or when taken in 2 300 mg doses. The results of the double-blind crossover studies demonstrated the effectiveness of the qd and bid dose and revealed no significant difference between the 2 dose regimens. They also showed the once-daily dose, a dose that is more convenient and easier to comply with, to be as effective as the twice-daily dose.
这项多中心临床试验针对类风湿性关节炎和骨关节炎患者开展，旨在评估和比较傍晚单次服用600毫克贝诺洛芬与分两次服用、每次300毫克的疗效和安全性。双盲交叉研究结果证明了每日一次剂量和每日两次剂量的有效性，且显示两种给药方案之间无显著差异。研究还表明，每日一次的剂量服用起来更方便、更易依从，其效果与每日两次的剂量相同。
