Gum O B
J Rheumatol Suppl. 1980;6:76-88.
Benoxaprofen, 400 to 600 mg daily, was compared to aspirin, 4,000 to 6,000 mg daily, or ibuprofen, 1,600 to 2,400 mg daily, in 2 multicolor clinical trials. The study design was double-blind and provided 28 wk of active drug therapy. Statistical analysis of the results showed benoxaprofen to be at least as effective as the 2 control drugs. More patients taking ibuprofen or aspirin discontinued therapy than patients taking benoxaprofen. Side effects occurred more frequently and lasted longer in patients who took aspirin during the study. Clinical laboratory examinations supported the long-term safety of benoxaprofen.
在两项多中心临床试验中，将每日服用400至600毫克的苯恶洛芬与每日服用4000至6000毫克的阿司匹林或每日服用1600至2400毫克的布洛芬进行了比较。研究设计为双盲试验，提供了28周的活性药物治疗。结果的统计分析表明，苯恶洛芬至少与两种对照药物一样有效。服用布洛芬或阿司匹林的患者比服用苯恶洛芬的患者更多地停止了治疗。在研究期间服用阿司匹林的患者中，副作用出现得更频繁，持续时间更长。临床实验室检查证实了苯恶洛芬的长期安全性。
