Siegel A J, Dawson D M
JAMA. 1980 Aug 8;244(6):580-2.
The MG isoenzyme of creatine kinase (CK MB) was strongly positive in the serum of a patient with alcoholic rhabdomyolysis, and it remained detectable by a standard qualitative assay over a two-year period without clinical or laboratory evidence of myocardial disease. MB isoenzyme was also demonstrated in a homogenate of skeletal muscle. Isoenzyme determinations in serum and tissue were repeated after dilution of toal CK activity to the range optimal for the assay (300 IU/L). Such dilution before isoenzyme separation rendered these samples negative for CK MB. The MB isoenzyme may be detectable in serum from peripheral sources in the presence of high total CK concentrations.
在一名酒精性横纹肌溶解患者的血清中，肌酸激酶（CK MB）的MG同工酶呈强阳性，并且在两年期间通过标准定性检测仍可检测到，而无心肌疾病的临床或实验室证据。在骨骼肌匀浆中也证实了MB同工酶的存在。在将总CK活性稀释至检测的最佳范围（300 IU/L）后，重复进行血清和组织中的同工酶测定。在同工酶分离前进行这样的稀释使得这些样本的CK MB呈阴性。在总CK浓度较高的情况下，外周来源的血清中可能检测到MB同工酶。
