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Neighbour and temperature effects on base-analogue-induced mutation in phage T4.

作者信息

Ronen A, Halevy C

出版信息

Mol Gen Genet. 1980;178(2):397-401. doi: 10.1007/BF00270490.

DOI:10.1007/BF00270490
PMID:6993847
Abstract

The effects of neighbouring base pairs and of temperature on mutation frequencies were measured at nonsense sites in the T4rII region. 2AP-induced AT leads to GC transition frequencies are insensitive to nearest-neighbour effects, while 5BU-induced ones are promoted by GC neighbours on the 5' side. The effect of temperature on 2AP- and 5BU-induced mutation frequencies shows no simple dependence on nearest neighbours. These results are incompatible with a unitary mechanism as explanation for the effects of nearest neighbours and temperature on base-analogue-induced mutagenesis.

摘要

相似文献

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引用本文的文献

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本文引用的文献

1
On the specificity of DNA polymerase.论DNA聚合酶的特异性
Proc Natl Acad Sci U S A. 1967 Mar;57(3):650-7. doi: 10.1073/pnas.57.3.650.
2
Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger-RNA.5-氟尿嘧啶对突变表型的逆转：一种研究信使核糖核酸中核苷酸序列的方法。
Proc Natl Acad Sci U S A. 1962 Apr 15;48(4):532-46. doi: 10.1073/pnas.48.4.532.
3
Genetic code: the 'nonsense' triplets for chain termination and their suppression.遗传密码：用于链终止的“无义”三联体及其抑制作用。
Nature. 1965 Jun 5;206(988):994-8. doi: 10.1038/206994a0.
4
The influence of neighboring base pairs upon base-pair substitution mutation rates.相邻碱基对对碱基对替换突变率的影响。
Proc Natl Acad Sci U S A. 1971 Apr;68(4):773-6. doi: 10.1073/pnas.68.4.773.
5
Nonsense codons.无义密码子。
Cold Spring Harb Symp Quant Biol. 1966;31:173-9. doi: 10.1101/sqb.1966.031.01.025.
6
Neighbor effects in the mutation of ochre triplets in the T 4 rII gene.
Mutat Res. 1971 Oct;13(2):109-13. doi: 10.1016/0027-5107(71)90002-9.
7
Mechanism of ribonucleic acid polymerase action. Effect of nearest neighbors on competition between uridine triphosphate and uridine triphosphate analogs for incorporation into ribonucleic acid.核糖核酸聚合酶的作用机制。相邻碱基对三磷酸尿苷和三磷酸尿苷类似物掺入核糖核酸的竞争作用的影响。
Biochemistry. 1967 Dec;6(12):3654-8. doi: 10.1021/bi00864a006.
8
Mutagen specificity and position effects on mutation in T4rII nonsense sites.
Mutat Res. 1976 Jan;34(1):21-34. doi: 10.1016/0027-5107(76)90258-x.
9
Marker effects on reversion of T4rII mutants.标记对T4rII突变体回复的影响。
Genetics. 1976 Nov;84(3):423-36. doi: 10.1093/genetics/84.3.423.
10
Site specificity and variability in the mutator and antimutator effects of phage T4 gene 43 mutants.噬菌体T4基因43突变体的诱变和抗诱变效应中的位点特异性和变异性。
Genetics. 1978 Dec;90(4):647-57. doi: 10.1093/genetics/90.4.647.