链脲佐菌素诱导的糖尿病及胰岛素治疗对大鼠心血管系统的影响。

The effects of streptozotocin-induced diabetes and insulin-treatment on the cardiovascular system of the rat.

作者信息

Pfaffman M A

出版信息

Res Commun Chem Pathol Pharmacol. 1980 Apr;28(1):27-41.

Abstract

In this study the cardiovascular effects of diabetes consisted of a decrease in the heart rate 6 days and in the blood pressure 7 weeks after the induction of streptozotocin-diabetes in rats. The diabetes-induced decrease in heart rate was reversed within 4 days after the institution of insulin-treatment, which also prevented the fall in blood pressure. Maximal KC1 (70 mM) and phenylephrine (10(-4)M)-induced contractures in aortae from diabetic rats were 57 and 48%, respectively, of those from control animals, while tissues from insulin-treated diabetic rats did not differ from controls. Theophylline (10(-2)M)-induced relaxation of the phenylephrine contracture in diabetic tissues was less than in control aortae while relaxation of the K-contracture was greater in control than in diabetic tissues. Insulin-treatment reversed the effects of diabetes on theophylline-induced relaxation of the KC1, but not the phenylephrine contracture. These findings indicate that insulin-treatment will either prevent or reverse diabetes-induced decreases in blood pressure, heart rate and vascular responsiveness to phenylephrine and CK1.

摘要

在本研究中，糖尿病对心血管系统的影响表现为，给大鼠注射链脲佐菌素诱导糖尿病后6天心率下降，7周后血压下降。糖尿病导致的心率下降在开始胰岛素治疗后4天内得到逆转，胰岛素治疗还可防止血压下降。糖尿病大鼠主动脉对最大氯化钾（70 mM）和去氧肾上腺素（10⁻⁴M）诱导的挛缩反应分别为对照动物的57%和48%，而胰岛素治疗的糖尿病大鼠的组织与对照无差异。茶碱（10⁻²M）诱导糖尿病组织中去氧肾上腺素挛缩的舒张作用小于对照主动脉，而钾离子挛缩的舒张作用在对照中大于糖尿病组织。胰岛素治疗逆转了糖尿病对茶碱诱导的氯化钾舒张作用的影响，但对去氧肾上腺素挛缩无影响。这些发现表明，胰岛素治疗可预防或逆转糖尿病引起的血压、心率下降以及血管对去氧肾上腺素和氯化钾反应性的降低。