Plachetka J R, Salomon N W, Larson D F, Copeland J G
Ann Thorac Surg. 1980 Jul;30(1):58-63. doi: 10.1016/s0003-4975(10)61203-9.
Prostacyclin (PGI2), a newly discovered short-acting prostaglandin that inhibits platelet aggregation, was evaluated as an agent for prevention of cardiopulmonary bypass-induced thrombocytopenia. Ten adult, splenectomized greyhounds were divided into three treatment groups prior to beginning 120 minutes of partial cardiopulmonary bypass. Group 1 animals received 300 units of heparin per kilogram of body weight, Group 2 animals received 300 units of heparin per kilogram plus PGI2, 1.5 micrograms per minute, and Group 3 animals received 300 units of heparin per kilogram plus PGI2 3.0 micrograms per minute. Bypass and PGI2 infusion were started simultaneously. Mean platelet counts of each group at 5 minutes were approximately 40% of prebypass levels. Additional platelet loss was seen in Groups 1 and 2 at 30, 60, and 120 minutes. However in Group 3, platelet counts at 30 and 60 minutes were essentially unchanged from prebypass levels. At 30, 60, and 120 minutes of cardiopulmonary bypass, the differences between Groups 1 and 3, and 2 and 3 are highly significant (p less than 0.01). We conclude that PGI2 is an effective agent for preserving platelet levels during experimental cardiopulmonary bypass. Furthermore, it is possible that platelet loss during cardiopulmonary bypass may be caused, in part, by an imbalance between PGI2 and thromboxane A2, which results in excessive platelet adhesion and aggregation.
前列环素（PGI2）是一种新发现的可抑制血小板聚集的短效前列腺素，被评估作为一种预防体外循环诱发血小板减少症的药物。在开始120分钟的部分体外循环之前，将10只成年脾切除的灵缇犬分为三个治疗组。第1组动物每公斤体重接受300单位肝素，第2组动物每公斤体重接受300单位肝素加每分钟1.5微克PGI2，第3组动物每公斤体重接受300单位肝素加每分钟3.0微克PGI2。体外循环和PGI2输注同时开始。每组在5分钟时的平均血小板计数约为体外循环前水平的40%。在第1组和第2组中，在30、60和120分钟时可见额外的血小板损失。然而，在第3组中，30和60分钟时的血小板计数与体外循环前水平基本没有变化。在体外循环30、60和120分钟时，第1组和第3组之间以及第2组和第3组之间的差异非常显著（p小于0.01）。我们得出结论，PGI2是在实验性体外循环期间维持血小板水平的有效药物。此外，体外循环期间的血小板损失可能部分是由PGI2和血栓素A2之间的失衡引起的，这导致血小板过度粘附和聚集。
