Klahr S, Hruska K, Martin K
Contrib Nephrol. 1980;20:129-37. doi: 10.1159/000384962.
The present studies demonstrate a stimulatory effect of intact parathyroid hormone on hepatic glucose production in vivo. This increased glucose production was accompanied by augmented alanine uptake by the liver. In addition, PTH increased the conversion of 14C-alanine to 14C-glucose. These results suggest that the increased hepatic release of glucose produced by PTH is mediated in part by increased gluconeogenesis. On the other hand, the synthetic 1-34 amino terminal fragment of PTH, which is not extracted by the liver, did not stimulate hepatic glucose production.
目前的研究表明，完整的甲状旁腺激素在体内对肝脏葡萄糖生成具有刺激作用。这种葡萄糖生成增加伴随着肝脏对丙氨酸摄取的增加。此外，甲状旁腺激素增加了14C-丙氨酸向14C-葡萄糖的转化。这些结果表明，甲状旁腺激素导致的肝脏葡萄糖释放增加部分是由糖异生增加介导的。另一方面，甲状旁腺激素的合成1-34氨基末端片段不能被肝脏摄取，不会刺激肝脏葡萄糖生成。
