1α-羟基胆钙化醇对骨骼矿物质代谢和骨形态发生的影响。
Effect of 1 alpha-hydroxycholecalciferol on the skeletal mineral metabolism and bone morphogenesis.
作者信息
Iwata H, Mutoh Y, Mizutani H, Nakagawa M
出版信息
Contrib Nephrol. 1980;22:74-88. doi: 10.1159/000385990.
PMID:6995017
Abstract
Administered 1 alpha-OH-D3 is hydrolyzed in liver and then converted to active 1 alpha, 25-(OH)2-D3. An increased serum calcium content was observed in rats administered 1 alpha-OH-D3. No calcium and magnesium increase was noticed in cortical bone due to 1 alpha-OH-D3 administration. Morphogenesis of bone and cartilage in implanted bone matrix in a group of 1 alpha-OH-D3 administered host rats seemed relatively increased to a slight extent.
摘要
给予的1α-羟维生素D3在肝脏中水解，然后转化为活性的1α,25-二羟维生素D3。在给予1α-羟维生素D3的大鼠中观察到血清钙含量增加。给予1α-羟维生素D3后，皮质骨中未发现钙和镁增加。在一组给予1α-羟维生素D3的宿主大鼠中，植入骨基质中骨和软骨的形态发生似乎有一定程度的相对增加。
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