Dryja T P, Zakov Z N, Albert D M
Int Ophthalmol Clin. 1980 Summer;20(2):177-90.
Our discussion of adenocarcinomas arising from the ciliary and iris epithelium, based upon a case report and a review of the literature, attempts summarize what little is known about these tumors. In most instances, the tumors arise from previously healthy eyes in middle-aged people. There appears to be no known way to make the diagnosis preoperatively. As long as the tumor has not extended outside the globe at the time of removal, the prognosis is excellent. The morphology of the tumors is virtually identical to those arising from the retinal pigment epithelium, with anaplastic epithelioid cells often forming tubes, cords, and acinuslike structures. In a few cases, tumors with these traits have extended from the globe and have eventually resulted in the death of the patients; one of these cases unquestionably arose from the iris and ciliary body epithelium. Knowledge of these tumors is in a primitive stage, and much clinical and pathological information is needed in order to determine their casue, diagnostic clinical features, and proper treatment.
基于一份病例报告及文献综述，我们对源自睫状体和虹膜上皮的腺癌展开讨论，旨在总结关于这些肿瘤的已知甚少的信息。在大多数情况下，肿瘤发生于中年人的既往健康眼睛。术前似乎尚无已知的诊断方法。只要在切除时肿瘤未扩散至眼球外，预后就极佳。这些肿瘤的形态与源自视网膜色素上皮的肿瘤几乎相同，间变的上皮样细胞常形成管状、条索状和腺泡样结构。在少数病例中，具有这些特征的肿瘤已从眼球扩散，最终导致患者死亡；其中一例无疑源自虹膜和睫状体上皮。对这些肿瘤的认识尚处于初级阶段，为了确定其病因、诊断性临床特征及恰当治疗，还需要大量临床和病理信息。
