Konrads A, Hummerich W, Vlaho M, Wambach G, Böttcher W, Meurer K A
Klin Wochenschr. 1980 Mar 3;58(5):233-6. doi: 10.1007/BF01476969.
Active renin was detected in 6 of 7 anephric patients (mean value: 0.72 +/- 0.27 microU/ml, n = 7; normals: 19.7 +/- 2.4 microU/ml, n = 10), using an assay method without intrinsic acid- or cryoactivation. Prorenin, measured as the difference between plasma renin concentration (PRC) before and after acid-activation in vitro, was present in considerable amounts in all patients (32.4 +/- 3.5 microU/ml; normals: 80.7 +/- 9.7 microU/ml). PRC after cryoactivation at--5 degrees C during 1 week was insignificantly lower than after acid-activation in the patients. There was a linear correlation between PRC after either activation procedure (p less than 0.01). Supine or upright posture did not influence active or inactive renin in the anephric subjects. Our studies show that low but significant levels of active renin and a considerable amount of prorenin are detectable in anephric patients. The data suggest that prorenin in normal subjects in a significant proportion is of extrarenal origin. Orthostasis has no effect on extrarenal active or inactive renin.
采用一种无内源性酸激活或冷激活的检测方法，在7例无肾患者中有6例检测到活性肾素（平均值：0.72±0.27微单位/毫升，n = 7；正常人为19.7±2.4微单位/毫升，n = 10）。以体外酸激活前后血浆肾素浓度（PRC）的差值来测定的肾素原，在所有患者中均大量存在（32.4±3.5微单位/毫升；正常人为80.7±9.7微单位/毫升）。在患者中，-5℃下冷冻激活1周后的PRC略低于酸激活后的PRC。两种激活方法后的PRC之间存在线性相关性（p<0.01）。仰卧或直立姿势对无肾受试者的活性或非活性肾素均无影响。我们的研究表明，在无肾患者中可检测到低水平但显著的活性肾素以及大量的肾素原。数据提示，正常受试者中相当一部分肾素原来源于肾外。直立位对肾外活性或非活性肾素无影响。
