van Herk G, de Zeeuw D
Contrib Nephrol. 1978;11:67-72. doi: 10.1159/000401779.
A new method has been developed for the continuous quantification of kidney blood flow, utilizing the unique physical and biological properties of the radioactive tracer couple: rubidium-81/krypton-81m. After intravenous injection, 81Rb concentrates primarily in the kidneys, where it continuously generates the radioactive inert gas 81mKr. This ultrashort-lived isotope is continuously washed out from the tissue at a rate proportional to the blood flow. The radiation emitted from within the kidney is externally detected and analyzed to yield the 81Rb/81mKr ratio. 21 animal experiments have confirmed that this ratio is at any time an accurate measure of the kidney perfusion. The 81Rb/81mKr ratio method has proved to provide a non-invasive way to selectively quantify the blood flow in each kidney, to monitor perfusion changes and to image the distribution of blood flow in a functional scintigram.
一种用于连续定量肾脏血流量的新方法已经开发出来，该方法利用了放射性示踪剂对铷-81/氪-81m的独特物理和生物学特性。静脉注射后，81Rb主要集中在肾脏中，在那里它持续产生放射性惰性气体81mKr。这种超短寿命的同位素以与血流量成比例的速率持续从组织中被冲洗出去。从肾脏内部发出的辐射被外部检测和分析，以得出81Rb/81mKr比值。21项动物实验证实，该比值在任何时候都是肾脏灌注的准确测量指标。事实证明，81Rb/81mKr比值法提供了一种非侵入性方法，可选择性地定量每个肾脏的血流量，监测灌注变化，并在功能性闪烁图中成像血流分布。
