Bacon B R, Rothman S A, Ricanati E S, Rashad F A
Arch Intern Med. 1980 Sep;140(9):1206-11.
We present here results of studies on four patients (three men, one woman) who had had cadaver renal transplants and in whom renal artery stenosis and hypertension developed. Erythropoietin-dependent erythrocytosis developed in association with these changes in the three men. All patients had stable renal function and the hypertension was well controlled. Absolute erythrocytosis thought to be secondary to local renal hypoxia due to decreased renal blood flow developed in two of the men. Erythrocytosis developed in the other man but his RBC mass was at the upper limit of normal. In these patients, we suspect that the erythropoietin-dependent erythrocytosis is secondary to intrarenal hypoxia due to renal artery stenosis. Erythrocytosis or elevated erythropoietin levels failed to develop in the woman despite severe renal artery stenosis. Possible reasons for this discrepancy are discussed.
我们在此展示了对4例患者（3名男性，1名女性）的研究结果，这些患者均接受了尸体肾移植，且出现了肾动脉狭窄和高血压。3名男性患者中，促红细胞生成素依赖性红细胞增多症与这些变化相关。所有患者肾功能稳定，高血压得到良好控制。两名男性患者因肾血流量减少导致局部肾缺氧，继发了绝对性红细胞增多症。另一名男性患者出现了红细胞增多症，但他的红细胞容积处于正常上限。在这些患者中，我们怀疑促红细胞生成素依赖性红细胞增多症是肾动脉狭窄导致肾内缺氧的继发表现。尽管该女性患者存在严重的肾动脉狭窄，但并未出现红细胞增多症或促红细胞生成素水平升高的情况。文中讨论了出现这种差异的可能原因。
